Carl Wilhelm von Zehender (May 21, 1819 - December 19, 1916) was a German ophthalmologist born in Bremen.
During his career he was an ophthalmologist in Neustrelitz, Berne and Rostock. At the University of Rostock he was chair of ophthalmology and co-founder of its ophthalmological clinic.
Zehender is considered a founder of ophthalmic microsurgery, as he introduced the practice of using a binocular vision corneal loupe during eye operations. He was founder and editor (1863-1899) of the ophthalmic journal Klinische Monatsblaetter fur Augenheilkunde, and was instrumental in the creation of the Heidelberger Ophthalmologische Gesellschaft, which was predecessor to the Deutsche Ophthalmologische Gesellschaft.